Product details
Background:
- Please choose product options by visiting Emx2 Polyclonal Antibody.
- Please choose product options by visiting LCMT2 rabbit pAb.
- Please choose product options by visiting BIOTIN*Polyclonal Goat Anti HBcAg.
- Please choose product options by visiting Ku80 mouse mAb.
AKAP8L rabbit pAb
Ucallm_WP6834-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | AKAP8L |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 71kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human AKAP8L |
| Specificity | This antibody detects endogenous levels of AKAP8L at Human |
| Gene Name | AKAP8L NAKAP NAKAP95 HRIHFB2018 |
| Protein Name | A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95) |
| Other Name | |
| Species | Human |
| Gene ID | 26993 |
| Uniprot | Q9ULX6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9R0L7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Nucleus matrix . Nucleus speckle . Nucleus, PML body . Cytoplasm . Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601). . |
| Tissue Expression | Ubiquitously expressed. Expressed in the brain cortex (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export . Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA . May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis . May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta . Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 . May be involved in regulation of pre-mRNA splicing .; (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters.; (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses.; (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity. |
Please login to post questions
Related products
