alpha Lactalbumin Monoclonal Antibody [9E9]
Ucallm_WM1021-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1, 4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | LALBA |
| Reactivity | Human |
| Applications | WB, IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 16kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000; IF 1:200; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 9E9 |
| Immunogen | Synthetic Peptide of alpha Lactalbumin |
| Specificity | The antibody detects endogenous alpha Lactalbumin proteins. |
| Gene Name | LALBA |
| Protein Name | Alpha-lactalbumin |
| Other Name | Alpha-lactalbumin; / Lactose synthase B protein; / Lysozyme-like protein 7 |
| Species | Human |
| Gene ID | 3906 |
| Uniprot | P00709, |
| Species.1 | Mouse |
| Gene ID.1 | 16770 |
| Uniprot.1 | P29752, |
| Species.2 | Rat |
| Gene ID.2 | 24528 |
| Uniprot.2 | P00714 |
| Cellular Localization | Secreted. |
| Tissue Expression | Mammary gland specific. Secreted in milk. |
| Signaling_pathway | |
| Research Areas | >>Galactose metabolism; / >>Metabolic pathways |
| Function | Function:Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.,similarity:Belongs to the glycosyl hydrolase 22 family.,subunit:Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).,tissue specificity:Mammary gland specific. Secreted in milk., |
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