Product details
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ANK3 rabbit pAb
Ucallm_WP8781-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ANK3 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 481kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ANK3 |
| Specificity | This antibody detects endogenous levels of ANK3 at Human, Mouse |
| Gene Name | ANK3 |
| Protein Name | Ankyrin-3 (ANK-3) (Ankyrin-G) |
| Other Name | |
| Species | Human |
| Gene ID | 288 |
| Uniprot | Q12955, |
| Species.1 | Mouse |
| Gene ID.1 | 11735 |
| Uniprot.1 | G5E8K5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton . Cell projection, axon . Cell membrane, sarcolemma . Cell junction, synapse, postsynaptic cell membrane . Lysosome . Cell membrane, sarcolemma, T-tubule . In skeletal muscle, localized at costameres and neuromuscular junctions. In macrophages, associated with lysosomes. .; [Isoform 5]: Cytoplasm, cytoskeleton . Golgi apparatus . |
| Tissue Expression | Expressed in brain, neurons, muscles and other tissues. |
| Signaling_pathway | |
| Research Areas | |
| Function | In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption .; [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. |
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