SKU: WM1357 Categories: ,

Annexin II [PTR1321] mouse mAb

Price range: $268.00 through $328.00

SKU: WM1357-50
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Product details

Background:
annexin A2(ANXA2) Homo sapiens This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetAnnexin II
ReactivityHuman, Mouse, Rat
ApplicationsWB, IF, ELISA
MW(Calculated)38kD
MW(Observed)37kD
Host SpeciesMouse
IsotypeIgG3,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityMonoclonal
Clone NumberRMMR1321
ImmunogenSynthesized peptide derived from human protein. AA range: 100-200
SpecificityThis antibody detects endogenous levels of Annexin II protein.
Gene NameANXA2 ANX2 ANX2L4 CAL1H LPC2D
Protein NameAnnexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
Other NameAnnexin A2; / Annexin II; / Annexin-2; / Calpactin I heavy chain; / Calpactin-1 heavy chain; / Chromobindin-8; / Lipocortin II; / Placental anticoagulant protein IV; / PAP-IV; / Protein I; / p36
SpeciesHuman
Gene ID302
UniprotP07355,
Species.1Mouse
Gene ID.112306
Uniprot.1P07356
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasmic
Tissue Expression
Signaling_pathway
Research Areas>>RNA degradation
FunctionCalcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 .
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