Name: ANT3 Polyclonal Antibody
SKU: WP11056
Price: 268 USD
Availability: InStock

Product details

Background:

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013],

Specifications

Size	50μL/100μL
Target	ANT3
Reactivity	Human
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	32kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human SLC25A6. AA range:121-170
Specificity	ANT3 Polyclonal Antibody detects endogenous levels of ANT3 protein.
Gene Name	SLC25A6
Protein Name	ADP/ATP translocase 3
Other Name	SLC25A6; / ANT3; / CDABP0051; / ADP/ATP translocase 3; / ADP; / ATP carrier protein 3; / ADP,ATP carrier protein, isoform T2; / ANT 2; / Adenine nucleotide translocator 3; / ANT 3; / Solute carrier family 25 member 6
Species	Human
Gene ID	293
Uniprot	P12236
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Mitochondrion inner membrane; Multi-pass membrane protein . Membrane; Multi-pass membrane protein . The complex formed with ARL2BP, ARL2 and SLC25A6/ANT3 is expressed in mitochondria (By similarity). May localize to non-mitochondrial membranes (By similarity). .
Tissue Expression	Expressed in erythrocytes (at protein level).
Signaling_pathway	Cellular Processes >> Cell growth and death >> Necroptosis;Cellular Processes >> Cell growth and death >> Cellular senescence;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Research Areas	>>Calcium signaling pathway; / >>cGMP-PKG signaling pathway; / >>Necroptosis; / >>Cellular senescence; / >>Neutrophil extracellular trap formation; / >>Alzheimer disease; / >>Parkinson disease; / >>Huntington disease; / >>Spinocerebellar ataxia; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Influenza A; / >>Human T-cell leukemia virus 1 infection; / >>Chemical carcinogenesis - reactive oxygen species; / >>Diabetic cardiomyopathy
Function	Function:Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.,miscellaneous:The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.,miscellaneous:The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,subunit:Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr.,