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APC5 Polyclonal Antibody
Ucallm_WP11068-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008],
Specifications
| Size | 50μL/100μL |
| Target | APC5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 85kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ANAPC5. AA range:151-200 |
| Specificity | APC5 Polyclonal Antibody detects endogenous levels of APC5 protein. |
| Gene Name | ANAPC5 |
| Protein Name | Anaphase-promoting complex subunit 5 |
| Other Name | ANAPC5; / APC5; / Anaphase-promoting complex subunit 5; / APC5; / Cyclosome subunit 5 |
| Species | Human |
| Gene ID | 51433 |
| Uniprot | Q9UJX4, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BTZ4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm, cytoskeleton, spindle . |
| Tissue Expression | Brain,Cerebellum,Cervix,Epithelium,Lung,Oesophagus,Periodontal liga |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Cell cycle;Organismal Systems >> Immune system >> IL-17 signaling pathway |
| Research Areas | >>Cell cycle; / >>Oocyte meiosis; / >>Ubiquitin mediated proteolysis; / >>IL-17 signaling pathway; / >>Progesterone-mediated oocyte maturation; / >>Human T-cell leukemia virus 1 infection |
| Function | Function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the APC5 family.,similarity:Contains 4 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits., |
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