Name: ApoA-IV Monoclonal Antibody
SKU: WM0026
Price: 268 USD
Availability: InStock

ApoA-IV Monoclonal Antibody

Ucallm_WM0026-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WM0026-50

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	ApoA-IV
Reactivity	Human
Applications	WB, ELISA
MW(Calculated)	45kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	4H5
Immunogen	Purified recombinant fragment of ApoA-IV (aa21-396) expressed in E. Coli.
Specificity	ApoA-IV Monoclonal Antibody detects endogenous levels of ApoA-IV protein.
Gene Name	APOA4
Protein Name	Apolipoprotein A-IV
Other Name	APOA4; / Apolipoprotein A-IV; / Apo-AIV; / ApoA-IV; / Apolipoprotein A4
Species	Human
Gene ID	337
Uniprot	P06727,
Species.1	Mouse
Gene ID.1
Uniprot.1	P06728
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Secreted.
Tissue Expression	Synthesized primarily in the intestine and secreted in plasma.
Signaling_pathway
Research Areas	>>Fat digestion and absorption; / >>Vitamin digestion and absorption; / >>Cholesterol metabolism; / >>Lipid and atherosclerosis
Function	Domain:Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.,Function:May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.,online information:The Singapore human mutation and polymorphism database,polymorphism:Eight alleles have been characterized (APOA-IV0 to APOA-IV7). APOA-IV1 is the major allele (90%), APOA-IV2 is also common (8%), the others are rare alleles.,similarity:Belongs to the apolipoprotein A1/A4/E family.,tissue specificity:Synthesized primarily in the intestine and secreted in plasma.,