AR α2C Polyclonal Antibody
Ucallm_WP11102-50
Price range: $268.00 through $328.00
Product details
Background:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | AR α2C |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 70kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor alpha-2C. AA range:336-385 |
| Specificity | AR α2C Polyclonal Antibody detects endogenous levels of AR α2C protein. |
| Gene Name | ADRA2C |
| Protein Name | Alpha-2C adrenergic receptor |
| Other Name | ADRA2C; / ADRA2L2; / ADRA2RL2; / Alpha-2C adrenergic receptor; / Alpha-2 adrenergic receptor subtype C4; / Alpha-2C adrenoreceptor; / Alpha-2C adrenoceptor; / Alpha-2CAR |
| Species | Human |
| Gene ID | 152 |
| Uniprot | P18825, |
| Species.1 | Mouse |
| Gene ID.1 | 11553 |
| Uniprot.1 | Q01337, |
| Species.2 | Rat |
| Gene ID.2 | 24175 |
| Uniprot.2 | P22086 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Brain,Donated clones,Kidney, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway |
| Research Areas | >>cGMP-PKG signaling pathway; / >>Neuroactive ligand-receptor interaction |
| Function | Function:Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.,polymorphism:The Del322-325 variant has a significant loss of function. It is approximately 10 times more frequent in African-Americans compared with Caucasians (allele frequencies 0.381 versus 0.040).,similarity:Belongs to the G-protein coupled receptor 1 family., |
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