ARA70 Polyclonal Antibody
Ucallm_WP11104-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009],
Specifications
| Size | 50μL/100μL |
| Target | NCOA4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, CoIP, ELISA |
| MW(Calculated) | |
| MW(Observed) | 70kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IP 1:50-200Not yet tested in other applications; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from NCOA4. at AA range: 320-400 |
| Specificity | ARA70 Polyclonal Antibody detects endogenous levels of NCOA4 protein. |
| Gene Name | NCOA4 |
| Protein Name | Nuclear receptor coactivator 4 |
| Other Name | NCOA4; / ARA70; / ELE1; / RFG; / Nuclear receptor coactivator 4; / NCoA-4; / Androgen receptor coactivator 70 kDa protein; / 70 kDa AR-activator; / 70 kDa androgen receptor coactivator; / Androgen receptor-associated protein of 70 kDa; / Ret-activating protein |
| Species | Human |
| Gene ID | 8031 |
| Uniprot | Q13772 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | nucleus,autolysosome, |
| Tissue Expression | Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Ferroptosis;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Thyroid cancer |
| Research Areas | >>Ferroptosis; / >>Pathways in cancer; / >>Thyroid cancer |
| Function | Alternative products:Additional isoforms seem to exist,Disease:A chromosomal aberration involving NCOA4 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Inversion inv(10)(q11.2; q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas.,Function:Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.,polymorphism:Polymorphisms are specific to isoform alpha. Not found in isoform beta. Could be encoded by two different genes.,subunit:Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner.,tissue specificity:Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform beta is only expressed in testis., |
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