ARP Polyclonal Antibody
Ucallm_WP15373-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014],
Specifications
| Size | 50μL/100μL |
| Target | ARP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 20kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human MANF. AA range:11-60 |
| Specificity | ARP Polyclonal Antibody detects endogenous levels of ARP protein. |
| Gene Name | MANF |
| Protein Name | Mesencephalic astrocyte-derived neurotrophic factor |
| Other Name | MANF; / ARMET; / ARP; / Mesencephalic astrocyte-derived neurotrophic factor; / Arginine-rich protein; / Protein ARMET |
| Species | Human |
| Gene ID | 7873 |
| Uniprot | P55145, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9CXI5, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P0C5H9 |
| Cellular Localization | Secreted . Endoplasmic reticulum lumen . Sarcoplasmic reticulum lumen . Retained in the endoplasmic reticulum (ER), and sarcoplasmic reticulum (SR) under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475, PubMed:29497057). . |
| Tissue Expression | Testis, |
| Signaling_pathway | |
| Research Areas | |
| Function | response to unfolded protein, response to organic substance, response to protein stimulus, |
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