Product details
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ASAH2 rabbit pAb
Ucallm_WP7893-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ASAH2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 86kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ASAH2 |
| Specificity | This antibody detects endogenous levels of ASAH2 at Human, Mouse,Rat |
| Gene Name | ASAH2 HNAC1 |
| Protein Name | Neutral ceramidase (N-CDase) (NCDase) (Acylsphingosine deacylase 2) (BCDase) (LCDase) (hCD) (N-acylsphingosine amidohydrolase 2) (Non-lysosomal ceramidase) [Cleaved into: Neutral ceramidase soluble form] |
| Other Name | |
| Species | Human |
| Gene ID | 56624 |
| Uniprot | Q9NR71, |
| Species.1 | Mouse |
| Gene ID.1 | 54447 |
| Uniprot.1 | Q9JHE3, |
| Species.2 | Rat |
| Gene ID.2 | 114104 |
| Uniprot.2 | Q91XT9 |
| Cellular Localization | [Neutral ceramidase]: Cell membrane; Single-pass type II membrane protein . Membrane raft; Single-pass type II membrane protein . Membrane, caveola; Single-pass type II membrane protein . Golgi apparatus membrane; Single-pass type II membrane protein . Mitochondrion . Secreted, extracellular exosome . Enriched in exosomes upon stimulation by cytokine (PubMed:24798654). Enriched in caveolae and lipid rafts (By similarity). The localization to the mitochondrion could not be confirmed (PubMed:15845354). .; [Neutral ceramidase soluble form]: Secreted . |
| Tissue Expression | Primarily expressed in intestine (PubMed:17334805). Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart (PubMed:10781606). The ubiquitous expression observed for ASAH2 might be an experimental artifact due to the paralog ASAH2B (PubMed:17334805). |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway |
| Research Areas | |
| Function | Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH . Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation . Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine . Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells . Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity). This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (By similarity). |
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