Product details
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ASTN2 rabbit pAb
Ucallm_WP8045-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ASTN2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 147kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ASTN2 |
| Specificity | This antibody detects endogenous levels of ASTN2 at Human, Mouse |
| Gene Name | ASTN2 KIAA0634 |
| Protein Name | Astrotactin-2 |
| Other Name | |
| Species | Human |
| Gene ID | 23245 |
| Uniprot | O75129, |
| Species.1 | Mouse |
| Gene ID.1 | 56079 |
| Uniprot.1 | Q80Z10 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Multi-pass membrane protein . Perikaryon . Cytoplasm, cell cortex . Early endosome . Late endosome . Cytoplasmic vesicle, clathrin-coated vesicle . Cytoplasmic vesicle . Integral membrane protein not detected at the cell membrane. Detected in cytoplasmic vesicles in the cell cortex, close to the anterior pole of migrating neurons. Detected at the base of the leading process in migrating neurons. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6). |
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