Name: ATF-6β Polyclonal Antibody
SKU: WP11187
Price: 268 USD
Availability: InStock

Product details

Background:

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],

Specifications

Size	50μL/100μL
Target	ATF-6β
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	90kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:20000; IF 1:50-200
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human ATF6B. AA range:401-450
Specificity	ATF-6β Polyclonal Antibody detects endogenous levels of ATF-6β protein.
Gene Name	ATF6B
Protein Name	Cyclic AMP-dependent transcription factor ATF-6 beta
Other Name	ATF6B; / CREBL1; / G13; / Cyclic AMP-dependent transcription factor ATF-6 beta; / cAMP-dependent transcription factor ATF-6 beta; / Activating transcription factor 6 beta; / ATF6-beta; / Protein G13; / cAMP response element-binding protein-related protein
Species	Human
Gene ID	1388
Uniprot	Q99941,
Species.1	Mouse
Gene ID.1
Uniprot.1	O35451
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Endoplasmic reticulum membrane; Single-pass type II membrane protein .; [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. .
Tissue Expression	Ubiquitous.
Signaling_pathway	Organismal Systems >> Endocrine system >> Insulin secretion;Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Organismal Systems >> Endocrine system >> Relaxin signaling pathway;Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Organismal Systems >> Nervous system >> Dopaminergic synapse;Organismal Systems >> Aging >> Longevity regulating pathway;Human Diseases >> Neurodegenerative disease >> Prion disease;Environmental Information Processing >> Signal transduction >> TNF signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas	>>cGMP-PKG signaling pathway; / >>Protein processing in endoplasmic reticulum; / >>PI3K-Akt signaling pathway; / >>Longevity regulating pathway; / >>Adrenergic signaling in cardiomyocytes; / >>TNF signaling pathway; / >>Dopaminergic synapse; / >>Insulin secretion; / >>Estrogen signaling pathway; / >>Thyroid hormone synthesis; / >>Aldosterone synthesis and secretion; / >>Relaxin signaling pathway; / >>Cortisol synthesis and secretion; / >>Parathyroid hormone synthesis, secretion and action; / >>Cushing syndrome; / >>Growth hormone synthesis, secretion and action; / >>Prion disease; / >>Cocaine addiction; / >>Amphetamine addiction; / >>Alcoholism; / >>Hepatitis B; / >>Human cytomegalovirus infection; / >>Human T-cell leukemia virus 1 infection; / >>Viral carcinogenesis; / >>Chemical carcinogenesis - receptor activation
Function	Domain:The basic domain functions as a nuclear localization signal.,Domain:The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.,Function:Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.,PTM:During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.,PTM:N-glycosylated.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,subunit:Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC).,tissue specificity:Ubiquitous.,

Please login to post questions

ATF-6β Polyclonal Antibody

Product details

Specifications

About Us

Support

Order

Menu

ATF-6β Polyclonal Antibody

Product details

Specifications

Related products

U-Blot® Glutamine Synthetase Rabbit mAb

U-Blot® CDC37 (Phospho Ser13) Rabbit mAb

U-Blot® SQSTM1/p62 Rabbit mAb

U-Blot® CDK6 Rabbit mAb

U-Blot® GAPDH Rabbit mAb

U-Blot® Hsp90 Rabbit mAb

Customer Reviews

Menu