Price range: $268.00 through $328.00
Background:
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | ATG12 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 15kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ATG12 AA range: 80-130 |
| Specificity | This antibody detects endogenous levels of ATG12 at Human/Mouse/Rat |
| Gene Name | ATG12 APG12 APG12L |
| Protein Name | ATG12 |
| Other Name | |
| Species | Human |
| Gene ID | 9140 |
| Uniprot | O94817, |
| Species.1 | Mouse |
| Gene ID.1 | 67526 |
| Uniprot.1 | Q9CQY1, |
| Species.2 | Rat |
| Gene ID.2 | 361321 |
| Uniprot.2 | Q2TBJ5 |
| Cellular Localization | Cytoplasm . Preautophagosomal structure membrane; Peripheral membrane protein . TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane. |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway |
| Research Areas | >>FoxO signaling pathway; / >>Autophagy - other; / >>Autophagy - animal; / >>NOD-like receptor signaling pathway; / >>RIG-I-like receptor signaling pathway; / >>Shigellosis |
| Function | Function:Required for autophagy.,similarity:Belongs to the ATG12 family.,subunit:Conjugated to ATG5.,tissue specificity:Ubiquitous., |
