Price range: $268.00 through $328.00
Background:
This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016],
| Size | 50μL/100μL |
| Target | ATX10 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 52kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 10-90 |
| Specificity | ATX10 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | ATXN10 SCA10 |
| Protein Name | Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein) |
| Other Name | |
| Species | Human |
| Gene ID | 25814 |
| Uniprot | Q9UBB4, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P28658, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9ER24 |
| Cellular Localization | Cytoplasm, perinuclear region . |
| Tissue Expression | Expressed in the central nervous system. |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia |
| Research Areas | >>Spinocerebellar ataxia |
| Function | Disease:Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10) [MIM:603516]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA).,similarity:Belongs to the ataxin-10 family., |
