Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthesized peptide derived from human BHLHA15
Specificity
This antibody detects endogenous levels of BHLHA15 at Human, Mouse,Rat
Gene Name
BHLHA15 BHLHB8 MIST1
Protein Name
Class A basic helix-loop-helix protein 15 (bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1)
Other Name
Species
Human
Gene ID
168620
Uniprot
Q7RTS1,
Species.1
Mouse
Gene ID.1
17341
Uniprot.1
Q9QYC3,
Species.2
Rat
Gene ID.2
25334
Uniprot.2
P70562
Cellular Localization
Nucleus .
Tissue Expression
Expressed in brain, liver, spleen and skeletal muscle.
Signaling_pathway
Research Areas
Function
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).