Price range: $268.00 through $328.00
Background:
induction:Up-regulated during monocytic differentiation., similarity:Contains 1 BAR domain., subunit:Interacts with BIN1., tissue specificity:Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.,
| Size | 50μL/100μL |
| Target | BIN2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 62kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 260-340 |
| Specificity | BIN2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | BIN2 BRAP1 |
| Protein Name | Bridging integrator 2 (Breast cancer-associated protein 1) |
| Other Name | |
| Species | Human |
| Gene ID | 51411 |
| Uniprot | Q9UBW5, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | D3Z6Q9, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q68FR2 |
| Cellular Localization | Cytoplasm . Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasm, cell cortex . Cell projection, phagocytic cup . Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure. . |
| Tissue Expression | Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues. |
| Signaling_pathway | |
| Research Areas | |
| Function | induction:Up-regulated during monocytic differentiation.,similarity:Contains 1 BAR domain.,subunit:Interacts with BIN1.,tissue specificity:Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues., |
