Name: BOB.1 [ABT-BOB1] mouse mAb
SKU: WM1574
Price: 268 USD
Availability: InStock

BOB.1 [ABT-BOB1] mouse mAb

Ucallm_WM1574-50

Price range: $268.00 through $328.00

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50μl

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SKU: WM1574-50

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Product details

Background:
disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6., function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers., PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation., similarity:Belongs to the POU2AF1 family., tissue specificity:B-cell specific.,

Specifications

Size	50μL/100μL
Target	BOB.1
Reactivity	Human, Mouse
Applications	IHC, ELISA
MW(Calculated)	27kD
MW(Observed)	35kD
Host Species	Mouse
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:50-200; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMM-BOB1
Immunogen	Synthesized peptide derived from human BOB.1 AA range: 150-256
Specificity	The antibody can specifically recognize human BOB.1 protein.
Gene Name	POU2AF1 OBF1
Protein Name	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)
Other Name	B cell Oct binding protein 1; / B cell specific coactivator OBF 1; / B cell specific coactivator OBF1; / B-cell-specific coactivator OBF-1; / BOB 1; / BOB-1; / OBF 1; / OBF1; / OBF1_HUMAN; / OCA B; / OCA-B; / OCAB; / OCT binding factor 1; / OCT-binding factor 1; / POU class 2 associating factor 1; / POU domain class 2 associating factor 1; / POU domain class 2-associating factor 1; / Pou2af1
Species	Human
Gene ID	5450
Uniprot	Q16633,
Species.1	Mouse
Gene ID.1	18985
Uniprot.1	Q64693
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nuclear, Cytoplasmic
Tissue Expression	B-cell specific (PubMed:7779176, PubMed:7859290). Detected in mainly in spleen, but also in thymus, periphral blood leukocyte and small intestine (PubMed:7779176, PubMed:7859290).
Signaling_pathway
Research Areas
Function	Disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3; 11)(q27; q23) with BCL6.,Function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,

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BOB.1 [ABT-BOB1] mouse mAb

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BOB.1 [ABT-BOB1] mouse mAb

Product details

Specifications

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