Name: BOB.1 [ABT-BOB1] mouse mAb
SKU: WM1574
Price: 268 USD
Availability: InStock

BOB.1 [ABT-BOB1] mouse mAb

Ucallm_WM1574-50

Price range: $268.00 through $328.00

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50μl

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SKU: WM1574-50

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Product details

Background:
disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6., function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers., PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation., similarity:Belongs to the POU2AF1 family., tissue specificity:B-cell specific.,

Specifications

Target	BOB.1
Reactivity	Human, Mouse
Applications	IHC, ELISA
MW(Calculated)	27kD
MW(Observed)	35kD
Host Species	Mouse
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	IHC 1:50-200; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Purification	The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	ABT-BOB1
Immunogen	Synthesized peptide derived from human BOB.1 AA range: 150-256
Sequence
Specificity	The antibody can specifically recognize human BOB.1 protein.
Gene Name	POU2AF1 OBF1
Protein Name	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)
Other Name	B cell Oct binding protein 1; / B cell specific coactivator OBF 1; / B cell specific coactivator OBF1; / B-cell-specific coactivator OBF-1; / BOB 1; / BOB-1; / OBF 1; / OBF1; / OBF1_HUMAN; / OCA B; / OCA-B; / OCAB; / OCT binding factor 1; / OCT-binding factor 1; / POU class 2 associating factor 1; / POU domain class 2 associating factor 1; / POU domain class 2-associating factor 1; / Pou2af1
Species	Human
Gene ID-1	5450
Uniprot	Q16633,
Species.1	Mouse
Gene ID-2	18985
Uniprot.1	Q64693
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	BOB.1 is a transcription activating factor necessary for the formation of follicular germinal center and the production of immunoglobulin. It works together with Oct-2 and is highly expressed in granulocytes of spleen and peripheral blood. It is mainly used for the typing of Hodgkin's lymphoma, mainly nodular lymphocytes. Hodgkin's lymphoma is positive and classical Hodgkin's lymphoma is negative.
Cellular Localization	Nuclear, Cytoplasmic
Tissue Expression	B-cell specific (PubMed:7779176, PubMed:7859290). Detected in mainly in spleen, but also in thymus, periphral blood leukocyte and small intestine (PubMed:7779176, PubMed:7859290).
Signaling_pathway
Research Areas
Function	Disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3; 11)(q27; q23) with BCL6.,Function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,
RRID