Bombesin Receptor 2 Polyclonal Antibody
Ucallm_WP5905-50
Price range: $268.00 through $328.00
Product details
Background:
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Specifications
| Size | 50μL/100μL |
| Target | Bombesin Receptor 2 |
| Reactivity | Mouse, Rat |
| Applications | WB, IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 50-70kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic Peptide of Bombesin Receptor 2 |
| Specificity | The antibody detects endogenous Bombesin Receptor 2 protein |
| Gene Name | |
| Protein Name | |
| Other Name | |
| Species | Human |
| Gene ID | 2925 |
| Uniprot | P30550, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P21729, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P52500 |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | |
| Function |
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