Name: BST-1 Polyclonal Antibody
SKU: WP11319
Price: 268 USD
Availability: InStock

BST-1 Polyclonal Antibody

Ucallm_WP11319-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP11319-100

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Product details

Background:

Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	BST-1
Reactivity	Human, Mouse, Rat, Monkey
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	34kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human BST1. AA range:71-120
Specificity	BST-1 Polyclonal Antibody detects endogenous levels of BST-1 protein.
Gene Name	BST1
Protein Name	ADP-ribosyl cyclase 2
Other Name	BST1; / ADP-ribosyl cyclase 2; / Bone marrow stromal antigen 1; / BST-1; / Cyclic ADP-ribose hydrolase 2; / cADPr hydrolase 2; / CD antigen CD157
Species	Human
Gene ID	683
Uniprot	Q10588,
Species.1	Mouse
Gene ID.1	12182
Uniprot.1	Q64277,
Species.2	Rat
Gene ID.2	81506
Uniprot.2	Q63072
Cellular Localization	Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Expression	Widely expressed.
Signaling_pathway
Research Areas	>>Nicotinate and nicotinamide metabolism; / >>Metabolic pathways; / >>Salivary secretion; / >>Pancreatic secretion
Function	Catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,Disease:Rheumatoid arthritis (RA) patients show enhanced expression of BST-1 transcripts in bone marrow stromal cell lines. This suggests that BST-1 overexpression may play a role in B-cell abnormalities in RA.,Function:Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.,similarity:Belongs to the ADP-ribosyl cyclase family.,subunit:Homodimer.,tissue specificity:Widely expressed.,