Price range: $268.00 through $328.00
Background:
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | c-Yes |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 61kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 11E6 |
| Immunogen | Purified recombinant fragment of c-Yes (aa10-193) expressed in E. Coli. |
| Specificity | c-Yes Monoclonal Antibody detects endogenous levels of c-Yes protein. |
| Gene Name | YES1 |
| Protein Name | Proto-oncogene tyrosine-protein kinase Yes |
| Other Name | YES1; / YES; / Tyrosine-protein kinase Yes; / Proto-oncogene c-Yes; / p61-Yes |
| Species | Human |
| Gene ID | 7525 |
| Uniprot | P07947 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. |
| Tissue Expression | Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Adherens junction |
| Research Areas | >>Adherens junction |
| Function | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating MCP/CD46.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:In epithelial cells infected with Neisseria gonorrhoeae, forms aggregates beneath bacterial microcolonies., |
