C13orf18 rabbit pAb
Ucallm_WP7494-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | RUBCNL |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 73kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human C13orf18 |
| Specificity | This antibody detects endogenous levels of C13orf18 at Human |
| Gene Name | KIAA0226L C13orf18 |
| Protein Name | Uncharacterized protein KIAA0226-like |
| Other Name | |
| Species | Human |
| Gene ID | 80183 |
| Uniprot | Q9H714, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q3TD16 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein . Associates with late autophagic structure (PubMed:28306502). Recruitment to autophagosome membrane is promoted by autophagic stimuli (PubMed:28306502). . |
| Tissue Expression | Expressed weakly in cervical carcinoma cell lines. |
| Signaling_pathway | |
| Research Areas | |
| Function | Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy . Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex . Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes . Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) . In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable). |
Please login to post questions
Related products
