Name: C1q-B Polyclonal Antibody
SKU: WP11339
Price: 268 USD
Availability: InStock

Product details

Background:

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008],

Specifications

Target	C1q-B
Reactivity	Human, Mouse, Rat
Applications	WB, FC, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	28kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-2000; Flow Cyt 1:50-200; IHC 1:100-500; IF/ICC1:100-500; ELISA 1:5000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human C1QB. AA range:161-210
Sequence
Specificity	C1q-B Polyclonal Antibody detects endogenous levels of C1q-B protein.
Gene Name	C1QB
Protein Name	Complement C1q subcomponent subunit B
Other Name	C1QB; / Complement C1q subcomponent subunit B
Species	Human
Gene ID-1	713
Uniprot	P02746,
Species.1	Mouse
Gene ID-2
Uniprot.1	P14106
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008],
Cellular Localization	Secreted.
Tissue Expression	Brain,Liver,
Signaling_pathway	Organismal Systems >> Immune system >> Complement and coagulation cascades;Human Diseases >> Immune disease >> Systemic lupus erythematosus;Human Diseases >> Neurodegenerative disease >> Prion disease
Research Areas	>>Complement and coagulation cascades; / >>Alcoholic liver disease; / >>Prion disease; / >>Pertussis; / >>Chagas disease; / >>Staphylococcus aureus infection; / >>Coronavirus disease - COVID-19; / >>Systemic lupus erythematosus
Function	Disease:Defects in C1QB are a cause of C1q deficiency [MIM:120570]. It is a rare genetic disorder which is associated with recurrent infections and a high prevalence of lupus erythematosus-like symptoms. It is characterized by a loss of activation of the complement classical pathway.,Function:C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.,online information:C1QB mutation db,PTM:O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.,similarity:Contains 1 C1q domain.,similarity:Contains 1 collagen-like domain.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, c1r and C1s in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.,
RRID

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C1q-B Polyclonal Antibody

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C1q-B Polyclonal Antibody

Product details

Specifications

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