Price range: $268.00 through $328.00
Background:
This gene encodes a member of a family of proteins that function as components of basement membranes and may play a role in cell adhesion. Mutations in this gene have been associated with late-onset retinal degeneration. The protein may be encoded by either a bicistronic transcript including sequence from the upstream membrane frizzled-related protein gene (MFRP), or by a monocistronic transcript expressed from an internal promoter. [provided by RefSeq, Jun 2013],
| Size | 50μL/100μL |
| Target | C1QT5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 26kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | C1QT5 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | C1QTNF5 CTRP5 UNQ303/PRO344 |
| Protein Name | Complement C1q tumor necrosis factor-related protein 5 |
| Other Name | |
| Species | Human |
| Gene ID | 114902 |
| Uniprot | Q9BXJ0, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8K479, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q5FVH0 |
| Cellular Localization | Secreted . |
| Tissue Expression | Brain,Fetal brain,Uterus, |
| Signaling_pathway | |
| Research Areas | |
| Function | developmental stage:Expressed in fetal brain.,Disease:Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD) [MIM:605670]. LORD is an autosomal dominant disorder characterized by onset in the fifth to sixth decade with night blindness and punctate yellow-white deposits in the retinal fundus, progressing to severe central and peripheral degeneration, with choroidal neovascularization and chorioretinal atrophy.,Disease:Defects in MFRP are the cause of microphthalmia MFRP-related (MCOPMFRP) [MIM:611040]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. MCOPMFRP is characterized by posterior microphthalmia, retinitis pigmentosa, foveoschisis and optic disc drusen.,Disease:Defects in MFRP are the cause of nanophthalmos 2 (NNO2) [MIM:609549]. NNO2 is a rare autosomal recessive disorder of eye development characterized by extreme hyperopia and small functional eyes.,Function:May play a role in eye development.,similarity:Contains 1 C1q domain.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 LDL-receptor class A domains.,tissue specificity:Specifically expressed in brain. Strongly expressed in medulla oblongata and to a lower extent in hippocampus and corpus callosum. Expressed in keratinocytes., |
