C6 Polyclonal Antibody
Ucallm_WP11346-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012],
Specifications
| Size | 50μL/100μL |
| Target | C6 |
| Reactivity | Human, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 105kD |
| MW(Observed) | 85-105kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human C6. AA range:221-270 |
| Specificity | C6 Polyclonal Antibody detects endogenous levels of C6 protein. |
| Gene Name | C6 |
| Protein Name | Complement component C6 |
| Other Name | C6; / Complement component C6 |
| Species | Human |
| Gene ID | 729 |
| Uniprot | P13671, |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 24237 |
| Uniprot.2 | Q811M5 |
| Cellular Localization | Secreted. |
| Tissue Expression | Blood,Ovary,Plasma, |
| Signaling_pathway | Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Complement and coagulation cascades;Human Diseases >> Immune disease >> Systemic lupus erythematosus;Human Diseases >> Neurodegenerative disease >> Prion disease |
| Research Areas | >>Complement and coagulation cascades; / >>Prion disease; / >>Coronavirus disease - COVID-19; / >>Systemic lupus erythematosus |
| Function | Disease:Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:612446].,Function:Involved in the formation of the lytic c5b-9m complex.,online information:C6 mutation db,polymorphism:The sequence shown is that of allotype C6 B.,PTM:All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 2 Sushi (CCP/SCR) domains.,similarity:Contains 3 TSP type-1 domains., |
Please login to post questions
Related products
