Product details
Background:
C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008],
C7 Polyclonal Antibody
Ucallm_WP15687-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | C7 |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 93kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the N-terminal region of human C7. AA range:100-150 |
| Specificity | C7 Polyclonal Antibody detects endogenous levels of C7 protein. |
| Gene Name | C7 |
| Protein Name | Complement component C7 |
| Other Name | C7; / Complement component C7 |
| Species | Human |
| Gene ID | 730 |
| Uniprot | P10643 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Liver,Placenta,Plasma,PNS, |
| Signaling_pathway | Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Complement and coagulation cascades;Human Diseases >> Immune disease >> Systemic lupus erythematosus;Human Diseases >> Neurodegenerative disease >> Prion disease |
| Research Areas | >>Complement and coagulation cascades; / >>Prion disease; / >>Coronavirus disease - COVID-19; / >>Systemic lupus erythematosus |
| Function | Disease:Defects in C7 are a cause of component C7 deficiency (C7D) [MIM:217070]. Patients with C7D suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis.,Function:C7 is a constituent of the membrane attack complex. C7 binds to C5b forming the C5b-7 complex, where it serves as a membrane anchor.,online information:C7 mutation db,PTM:C7 has 28 disulfide bridges.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 2 Sushi (CCP/SCR) domains.,similarity:Contains 2 TSP type-1 domains.,subunit:Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes., |
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