SKU: WP11358 Categories: ,

CA XIV Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11358-100
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Product details

Background:

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCA XIV
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)34kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CA14. AA range:161-210
SpecificityCA XIV Polyclonal Antibody detects endogenous levels of CA XIV protein.
Gene NameCA14
Protein NameCarbonic anhydrase 14
Other NameCA14; / Carbonic anhydrase 14; / Carbonate dehydratase XIV; / Carbonic anhydrase XIV; / CA-XIV
SpeciesHuman
Gene ID23632
UniprotQ9ULX7,
Species.1Mouse
Gene ID.123831
Uniprot.1Q9WVT6
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Single-pass type I membrane protein .
Tissue ExpressionHigh expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.
Signaling_pathway
Research Areas>>Nitrogen metabolism; / >>Metabolic pathways
FunctionCatalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,Function:Reversible hydration of carbon dioxide.,similarity:Belongs to the alpha-carbonic anhydrase family.,tissue specificity:High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.,
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