SKU: WP11382 Categories: ,

Calgizzarin Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11382-100
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Product details

Background:

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetS100A11
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF, ELISA
MW(Calculated)12kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from Calgizzarin . at AA range: 30-110
SpecificityCalgizzarin Polyclonal Antibody detects endogenous levels of Calgizzarin protein.
Gene NameS100A11
Protein NameProtein S100-A11
Other NameS100A11; / MLN70; / S100C; / Protein S100-A11; / Calgizzarin; / Metastatic lymph node gene 70 protein; / MLN 70; / Protein S100-C; / S100 calcium-binding protein A11
SpeciesHuman
Gene ID6282
UniprotP31949,
Species.1Mouse
Gene ID.120195
Uniprot.1P50543,
Species.2Rat
Gene ID.2445415
Uniprot.2Q6B345
Cellular LocalizationCytoplasm . Nucleus .
Tissue ExpressionBrain,Epithelium,Keratinocyte,Lung,Mammary carcinoma,Placenta,Urina
Signaling_pathway
Research Areas
FunctionFunction:Facilitates the differentiation and the cornification of keratinocytes.,miscellaneous:Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins.,PTM:Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Homodimer; disulfide-linked.,
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