SKU: WP11385 Categories: ,

Calnexin Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11385-100
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Product details

Background:

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],

Specifications

TargetCalnexin
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)90kD
Host SpeciesRabbit
IsotypeIgG
Conjugate
ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000;IHC: 1:100-300;ELISA 1:20000;IF 1:100-300;Not yet tested in other applications.
CompositionLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification ProcessThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage Condition-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human Calnexin. AA range:543-592
Sequence
SpecificityCalnexin Polyclonal Antibody detects endogenous levels of Calnexin protein.
Gene NameCANX
Protein NameCalnexin
AliasCANX;Calnexin;IP90;Major histocompatibility complex class I antigen-binding protein p88;p90
Organism-1Human
Gene ID-1821
SwissProt-1P27824
Organism-2Mouse
Gene ID-212330
SwissProt-2P35564
Organism-3Rat
Gene ID-329144
SwissProt-3P35565
Organism-4
Gene ID-4
SwissProt-4
Cellular LocalizationEndoplasmic reticulum membrane ; Single-pass type I membrane protein . Endoplasmic reticulum . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232). .
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