SKU: WM0646 Categories: ,

Calumenin mouse mAb

Price range: $268.00 through $328.00

SKU: WM0646-50
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Product details

Background:
calumenin(CALU) Homo sapiens The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008],

Specifications

Size50μL/100μL
TargetCalumenin
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)
MW(Observed)37kD
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:1000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number17F6
ImmunogenPurified recombinant human Calumenin protein fragments expressed in E.coli.
SpecificityThis antibody detects endogenous levels of Calumenin and does not cross-react with related proteins.
Gene Namecalu
Protein Name
Other NameCALU; / CALU_HUMAN; / Calumenin 1; / Calumenin 2; / Calumenin; / Crocalbin; / crocalbin-like protein; / FLJ90608; / IEF SSP 9302; / multiple EF-hand protein; / OTTHUMP00000212712; / OTTHUMP00000212713; / OTTHUMP00000212714; / OTTHUMP00000212715.
SpeciesHuman
Gene ID813
UniprotO43852,
Species.1Mouse
Gene ID.1
Uniprot.1O35887
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationEndoplasmic reticulum membrane . Golgi apparatus . Secreted . Melanosome . Sarcoplasmic reticulum lumen . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .
Tissue ExpressionUbiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.
Signaling_pathway
Research Areas
FunctionFunction:Involved in regulation of vitamin K-dependent carboxylation of multiple amino-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity.,similarity:Belongs to the CREC family.,similarity:Contains 6 EF-hand domains.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with GGCX.,tissue specificity:Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.,
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