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CAMSAP2 rabbit pAb
Ucallm_WP5986-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | CAMSAP2 |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 164kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CAMSAP2 |
| Specificity | This antibody detects endogenous levels of CAMSAP2 at Human |
| Gene Name | CAMSAP2 CAMSAP1L1 KIAA1078 |
| Protein Name | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) |
| Other Name | |
| Species | Human |
| Gene ID | 23271 |
| Uniprot | Q08AD1, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8C1B1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton . Golgi apparatus . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm . Associated with the minus-end of microtubules and also detected at the centrosomes (PubMed:23169647, PubMed:24486153, PubMed:24908486, PubMed:24706919, PubMed:27666745, PubMed:28814570). Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound (PubMed:24486153). The length of CAMSAP2-decorated stretches on the minus-end of microtubules depends on MAPRE1/EB1 and MAPRE3/EB3, which promote elongation of CAMSAP2-decorated microtubule stretches (PubMed:28814570). Recruited to the Golgi apparatus by AKAP9 and PDE4DIP isoform 13/MMG8/SMYLE (PubMed:27666745). In neurons, localizes to the minus-end of microtubules in axon and dendrites (PubMed:24908486). . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization . Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization . Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization . In addition, it also reduces the velocity of microtubule polymerization . Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes . Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement . Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation . Through the microtubule cytoskeleton, regulates the autophagosome transport . |
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