Name: CARD 11 Polyclonal Antibody
SKU: WP11406
Price: 268 USD
Availability: InStock

CARD 11 Polyclonal Antibody

Ucallm_WP11406-50

Price range: $268.00 through $328.00

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100μl

50μl

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SKU: WP11406-100

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Product details

Background:

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	CARD11
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	130kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human CARD11. AA range:10-59
Specificity	CARD 11 Polyclonal Antibody detects endogenous levels of CARD 11 protein.
Gene Name	CARD11 CARMA1
Protein Name	Caspase recruitment domain-containing protein 11
Other Name	CARD11; / CARMA1; / Caspase recruitment domain-containing protein 11; / CARD-containing MAGUK protein 1; / Carma 1
Species	Human
Gene ID	84433
Uniprot	Q9BXL7,
Species.1	Mouse
Gene ID.1	108723
Uniprot.1	Q8CIS0
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm . Membrane raft . Colocalized with DPP4 in membrane rafts. .
Tissue Expression	Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.
Signaling_pathway	Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> B cell receptor signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway
Research Areas	>>NF-kappa B signaling pathway; / >>T cell receptor signaling pathway; / >>B cell receptor signaling pathway
Function	Caution:Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.,Function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.,similarity:Contains 1 CARD domain.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:CARD11 and BCL10 bind to each other by CARD-CARD interaction.,tissue specificity:Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.,