Product details
Background:
CARD15/NOD2 rabbit pAb
Ucallm_WP9033-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | NOD2 |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 114kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CARD15/NOD2 |
| Specificity | This antibody detects endogenous levels of CARD15/NOD2 at Human |
| Gene Name | NOD2 CARD15 IBD1 |
| Protein Name | Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1) |
| Other Name | |
| Species | Human |
| Gene ID | 64127 |
| Uniprot | Q9HC29, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8K3Z0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane . Cytoplasm . Membrane . Mitochondrion . Basolateral cell membrane . |
| Tissue Expression | Mainly expressed in monocytes (PubMed:11087742). Expressed also in intestinal mucosa, mainly in Paneth cells and, at lower extent, in the glandular epithelium (PubMed:22700971). |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Human Diseases >> Immune disease >> Inflammatory bowel disease;Environmental Information Processing >> Signal transduction >> TNF signaling pathway |
| Research Areas | |
| Function | Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and plays an important role in gastrointestinal immunity . Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling . This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages . Component of an autophagy-mediated antibacterial pathway together with ATG16L1 . Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon . Besides recognizing pathogens, participates in surveillance of cellular homeostasis through sensing and binding to the cytosolic metabolite sphingosine-1-phosphate and then initating inflammation process . |
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