Price range: $268.00 through $328.00
Background:
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010],
| Size | 50μL/100μL |
| Target | Cathepsin S |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 36kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | CATS Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | CTSS |
| Protein Name | Cathepsin S (EC 3.4.22.27) |
| Other Name | |
| Species | Human |
| Gene ID | 1520 |
| Uniprot | P25774, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O70370, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q02765 |
| Cellular Localization | Lysosome . Secreted . Cytoplasmic vesicle, phagosome . |
| Tissue Expression | Alveolar macrophage,Pancreas,Testis, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Transport and catabolism >> Lysosome;Cellular Processes >> Cell growth and death >> Apoptosis;Organismal Systems >> Immune system >> Antigen processing and presentation |
| Research Areas | >>Lysosome; / >>Phagosome; / >>Apoptosis; / >>Antigen processing and presentation; / >>Tuberculosis |
| Function | Catalytic activity:Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.,Function:Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.,similarity:Belongs to the peptidase C1 family.,subunit:Monomer., |
