Product details
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CCDC88C rabbit pAb
Ucallm_WP7535-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | CCDC88C |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 223kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CCDC88C |
| Specificity | This antibody detects endogenous levels of CCDC88C at Human, Mouse |
| Gene Name | CCDC88C DAPLE KIAA1509 |
| Protein Name | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) |
| Other Name | |
| Species | Human |
| Gene ID | 440193 |
| Uniprot | Q9P219, |
| Species.1 | Mouse |
| Gene ID.1 | 68339 |
| Uniprot.1 | Q6VGS5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Cell junction . Enriched at apical cell junctions. . |
| Tissue Expression | |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Wnt signaling pathway |
| Research Areas | |
| Function | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling . Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling . Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation . Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling . Promotes apical constriction of cells via ARHGEF18 . |
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