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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/CD166 Monoclonal Antibody
SKU: WM0084 Categories: ,

CD166 Monoclonal Antibody

Ucallm_WM0084-50

Price range: $268.00 through $328.00

SKU: WM0084-50
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Product details

Background:
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011],

Specifications

Size50μL/100μL
TargetCD166
ReactivityHuman
ApplicationsWB, ELISA
MW(Calculated)65kD
MW(Observed)
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationAffinity purification
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number3D9
ImmunogenPurified recombinant fragment of CD166 (aa405-524) expressed in E. Coli.
SpecificityCD166 Monoclonal Antibody detects endogenous levels of CD166 protein.
Gene NameALCAM
Protein NameCD166 antigen
Other NameALCAM; / MEMD; / CD166 antigen; / Activated leukocyte cell adhesion molecule; / CD antigen CD166
SpeciesHuman
Gene ID214
UniprotQ13740,
Species.1Mouse
Gene ID.1
Uniprot.1Q61490
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse (PubMed:15294938). .; [Isoform 3]: Secreted .
Tissue ExpressionDetected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422).
Signaling_pathwayEnvironmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas>>Cell adhesion molecules
FunctionDomain:The CD6 binding site is located in the N-terminal Ig-like domain.,Function:Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.,similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.,
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