Name: U-Blot® CD20 Rabbit mAb
SKU: WR4236
Price: 268 USD
Availability: InStock

U-Blot® CD20 Rabbit mAb

Western blot analysis of lysates from Raji cells, using CD20 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

WR4236 Western blot analysis of lysates from Raji cells, using CD20 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

Price range: $268.00 through $328.00

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100μl

50μl

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SKU: WR4236-50

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Product details

Background:This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	CD20
Reactivity	Human
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	33kD
MW(Observed)	36kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:500-1:5000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0419R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	MS4A1 CD20
Protein Name	CD20
Other Name	B-lymphocyte antigen CD20; / B-lymphocyte surface antigen B1; / Bp35; / Leukocyte surface antigen Leu-16; / Membrane-spanning 4-domains subfamily A member 1; / CD antigen CD20
Species	Human
Gene ID	931
Uniprot	P11836,
Species.1	Mouse
Gene ID.1	12482
Uniprot.1	P19437,
Species.2	Rat
Gene ID.2	309217
Uniprot.2	D4A4Y3
Cellular Localization	Membrane
Tissue Expression	Expressed on B-cells.
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage
Research Areas	>>Hematopoietic cell lineage
Function	Caution:Epitope 1, mapped in PubMed:16785532, is predicted to be buried in the membrane. Its accessibility to the extracellular space, and thus to antibody recognition, is not explained.,Function:This protein may be involved in the regulation of B-cell activation and proliferation.,online information:CD20 entry,pharmaceutical:Monoclonal antibodies(mAb) against CD20 are used to treat B-cell non-Hodgkin's lymphoma (NHL). These antibodies include Rituximab (Mabthera), Britumomab (Zevalin) and Tositumomab (Bexxar). CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively, mAb can mediate complement-dependent cytotoxicity.,PTM:Phosphorylated. Might be functionally regulated by protein kinase(s).,similarity:Belongs to the MS4A family.,tissue specificity:Expressed on B-cells.,

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U-Blot® CD20 Rabbit mAb

Product details

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U-Blot® CD20 Rabbit mAb

Product details

Specifications

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