Name: CD32-C Polyclonal Antibody
SKU: WP11500
Price: 268 USD
Availability: InStock

Product details

Background:

caution:Has sometimes been attributed to correspond to FcR-IIB., caution:Has sometimes been attributed to correspond to FcR-IIC., disease:A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression., domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases., domain:Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation., function:Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells., function:Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis., similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains., subunit:Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1., tissue specificity:Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells., tissue specificity:Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.,

Specifications

Size	50μL/100μL
Target	CD32
Reactivity	Human
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	35kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human FCGR2C. AA range:251-300
Specificity	CD32-C Polyclonal Antibody detects endogenous levels of CD32-C protein.
Gene Name	FCGR2C
Protein Name	Low affinity immunoglobulin gamma Fc region receptor II-c
Other Name	FCGR2C; / CD32; / FCG2; / IGFR2; / Low affinity immunoglobulin gamma Fc region receptor II-c; / IgG Fc receptor II-c; / CDw32; / Fc-gamma RII-c; / Fc-gamma-RIIc; / FcRII-c; / CD antigen CD32
Species	Human
Gene ID	9103
Uniprot	P31995
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	[Isoform IIC4]: Cytoplasm .; [Isoform IIC3]: Cell membrane; Single-pass type I membrane protein.; [Isoform IIC2]: Cell membrane; Single-pass type I membrane protein.; [Isoform IIC1]: Cell membrane; Single-pass type I membrane protein.
Tissue Expression	Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Development and regeneration >> Osteoclast differentiation
Research Areas	>>Phagosome; / >>Osteoclast differentiation; / >>Leishmaniasis; / >>Staphylococcus aureus infection; / >>Tuberculosis
Function	Caution:Has sometimes been attributed to correspond to FcR-IIB.,Caution:Has sometimes been attributed to correspond to FcR-IIC.,Disease:A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1; 22)(q22; q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.,Domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,Domain:Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation.,Function:Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.,Function:Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1.,tissue specificity:Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.,tissue specificity:Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.,