CD38 [PTR1378] recombinant mouse mAb
Ucallm_WM1329-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded byThis gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein.This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Specifications
| Size | 50μL/100μL |
| Target | CD36 |
| Reactivity | Human |
| Applications | FC, ELISA |
| MW(Calculated) | |
| MW(Observed) | 90kD |
| Host Species | Mouse |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | Please check the information on the tube |
| Clonality | Monoclonal |
| Clone Number | RMMR1380 |
| Immunogen | Purified recombinant Human CD38 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD38 protein. |
| Gene Name | CD38 |
| Protein Name | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38) |
| Other Name | CD38; / ADP-ribosyl cyclase 1; / Cyclic ADP-ribose hydrolase 1; / cADPr hydrolase 1; / T10; / CD antigen CD38; / CD38 nanobody |
| Species | Human |
| Gene ID | 948 |
| Uniprot | P28907, |
| Species.1 | Mouse |
| Gene ID.1 | 12491 |
| Uniprot.1 | Q08857, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q07969 |
| Cellular Localization | Membrane; Single-pass type II membrane protein. |
| Tissue Expression | Adipocyte,Liver,Mammary gland,Milk,Placenta,Platelet,Skeletal muscle, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Organismal Systems >> Endocrine system >> PPAR signaling pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction |
| Research Areas | >>PPAR signaling pathway; / >>Phagosome; / >>AMPK signaling pathway; / >>ECM-receptor interaction; / >>Hematopoietic cell lineage; / >>Adipocytokine signaling pathway; / >>Insulin resistance; / >>Fat digestion and absorption; / >>Cholesterol metabolism; / >>Malaria; / >>Diabetic cardiomyopathy; / >>Lipid and atherosclerosis |
| Function | Catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,developmental stage:Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.,enzyme regulation:ATP inhibits the hydrolyzing activity.,Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.,online information:CD38 entry,similarity:Belongs to the ADP-ribosyl cyclase family.,tissue specificity:Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma., |
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