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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/CEL Polyclonal Antibody
SKU: WP11574 Categories: ,

CEL Polyclonal Antibody

Ucallm_WP11574-50

Price range: $268.00 through $328.00

SKU: WP11574-100
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Product details

Background:

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCEL
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF, ELISA
MW(Calculated)78kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from the Internal region of human CEL.
SpecificityCEL Polyclonal Antibody detects endogenous levels of CEL protein.
Gene NameCEL
Protein NameBile salt-activated lipase
Other NameCEL; / BAL; / Bile salt-activated lipase; / BAL; / Bile salt-stimulated lipase; / BSSL; / Bucelipase; / Carboxyl ester lipase; / Cholesterol esterase; / Pancreatic lysophospholipase; / Sterol esterase
SpeciesHuman
Gene ID1056
UniprotP19835,
Species.1Mouse
Gene ID.1
Uniprot.1Q64285
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationSecreted .
Tissue ExpressionMammary gland and pancreas. Detected in pancreatic and duodenal juice (at protein level) (PubMed:21784842). Expressed by eosinophils.
Signaling_pathway
Research Areas>>Steroid biosynthesis; / >>Glycerolipid metabolism; / >>Metabolic pathways; / >>Pancreatic secretion; / >>Fat digestion and absorption
FunctionCatalytic activity:A steryl ester + H(2)O = a sterol + a fatty acid.,Catalytic activity:Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.,Disease:Defects in CEL are a cause of maturity-onset diabetes of the young type 8 with exocrine dysfunction (MODY8) [MIM:609812]; also known as diabetes and pancreatic exocrine dysfunction (DPED). MODY [MIM:606391] is an autosomal dominant form of diabetes mellitus. The pancreas serves both endocrine and exocrine functions. The endocrine cells are found in the islets of Langerhans. They synthesize insulin and other hormones, and are involved in the pathogenesis of diabetes mellitus. The exocrine cells produce bicarbonate and digestive enzymes and are involved in the pathogenesis of pancreatic malabsorption. The localization of the islets within exocrine pancreatic tissue is suggestive of an interdependency and cross-talk between these two cell populations in their normal and in their abnormal function.,enzyme regulation:Activated by bile salts containing a 7-hydroxyl group.,Function:Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.,similarity:Belongs to the type-B carboxylesterase/lipase family.,tissue specificity:Mammary gland and pancreas.,
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