Price range: $268.00 through $328.00
Background:
CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | CENPL |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 37kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 100-180 |
| Specificity | CENPL Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | CENPL C1orf155 ICEN33 |
| Protein Name | Centromere protein L (CENP-L) (Interphase centromere complex protein 33) |
| Other Name | |
| Species | Human |
| Gene ID | 91687 |
| Uniprot | Q8N0S6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q3U3S3, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q3ZAU7 |
| Cellular Localization | Nucleus . Chromosome, centromere . Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. |
| Tissue Expression | Eye,Muscle,Synovial cell,Urinary bladder, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.,subcellular location:Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.,subunit:Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU., |
