Name: CERU Polyclonal Antibody
SKU: WP1006
Price: 268 USD
Availability: InStock

CERU Polyclonal Antibody

Ucallm_WP1006-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP1006-100

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:

The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012],

Specifications

Size	50μL/100μL
Target	CERU
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	117kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein
Specificity	CERU Polyclonal Antibody detects endogenous levels of protein.
Gene Name	CP
Protein Name	Ceruloplasmin (Ferroxidase)
Other Name
Species	Human
Gene ID	1356
Uniprot	P00450,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q61147,
Species.2	Rat
Gene ID.2
Uniprot.2	P13635
Cellular Localization	Secreted. Colocalizes with GCP1 in secretory intracellular compartments. .
Tissue Expression	Expressed by the liver and secreted in plasma.
Signaling_pathway	Cellular Processes >> Cell growth and death >> Ferroptosis
Research Areas	>>Porphyrin metabolism; / >>Ferroptosis
Function	Catalytic activity:4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.,cofactor:Binds 6 copper ions per monomer.,Disease:Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.,Disease:Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.,Function:Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.,online information:Ceruloplasmin entry,similarity:Belongs to the multicopper oxidase family.,similarity:Contains 3 F5/8 type A domains.,similarity:Contains 6 plastocyanin-like domains.,tissue specificity:Expressed by the liver and secreted in plasma.,

Please login to post questions

CERU Polyclonal Antibody

Product details

Specifications

About Us

Support

Order

Menu

CERU Polyclonal Antibody

Product details

Specifications

Related products

U-Blot® VEGF Receptor 1 Rabbit mAb

U-Blot® HDAC2 Rabbit mAb

Acetyl Lysine Monoclonal Antibody [10B10]

U-Blot® PMS2 Rabbit mAb

U-Blot® CDK6 Rabbit mAb

U-Blot® Cyclin B1 (Phospho Ser126) Rabbit mAb

Customer Reviews

Menu