SKU: WP11614 Categories: ,

ChemR23 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11614-100
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Product details

Background:

developmental stage:Expressed during bone development., function:Orphan receptor. Could be a chemotactic peptide receptor. May have a function in bone metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2)., similarity:Belongs to the G-protein coupled receptor 1 family., tissue specificity:Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands.,

Specifications

Size50μL/100μL
TargetChemR23
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)42kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:100-300; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CMKLR1. AA range:221-270
SpecificityChemR23 Polyclonal Antibody detects endogenous levels of ChemR23 protein.
Gene NameCMKLR1
Protein NameChemokine-like receptor 1
Other NameCMKLR1; / CHEMR23; / DEZ; / Chemokine-like receptor 1; / G-protein coupled receptor ChemR23; / G-protein coupled receptor DEZ
SpeciesHuman
Gene ID1240
UniprotQ99788,
Species.1Mouse
Gene ID.114747
Uniprot.1P97468,
Species.2Rat
Gene ID.2
Uniprot.2O35786
Cellular LocalizationCell membrane; Multi-pass membrane protein . Internalizes efficiently in response to RARRES2. .
Tissue ExpressionProminently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.
Signaling_pathway
Research Areas
Functiondevelopmental stage:Expressed during bone development.,Function:Orphan receptor. Could be a chemotactic peptide receptor. May have a function in bone metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands.,
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