CHIA rabbit pAb
Ucallm_WP6891-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | CHIA |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 52kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CHIA |
| Specificity | This antibody detects endogenous levels of CHIA at Human, Mouse,Rat |
| Gene Name | CHIA |
| Protein Name | Acidic mammalian chitinase (AMCase) (Lung-specific protein TSA1902) |
| Other Name | |
| Species | Human |
| Gene ID | 27159 |
| Uniprot | Q9BZP6, |
| Species.1 | Mouse |
| Gene ID.1 | 81600 |
| Uniprot.1 | Q91XA9, |
| Species.2 | Rat |
| Gene ID.2 | 113901 |
| Uniprot.2 | Q6RY07 |
| Cellular Localization | [Isoform 1]: Secreted. Secretion depends on EGFR activity.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm. |
| Tissue Expression | Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung. |
| Signaling_pathway | |
| Research Areas | |
| Function | Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. |
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