SKU: WP11635 Categories: ,

CIDE-3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11635-100
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Product details

Background:

cell death inducing DFFA like effector c(CIDEC) Homo sapiens This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],

Specifications

Size50μL/100μL
TargetCIDE-3
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF, ELISA
MW(Calculated)27kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CIDEC. AA range:189-238
SpecificityCIDE-3 Polyclonal Antibody detects endogenous levels of CIDE-3 protein.
Gene NameCIDEC
Protein NameCell death activator CIDE-3
Other NameCIDEC; / FSP27; / Cell death activator CIDE-3; / Cell death-inducing DFFA-like effector protein C; / Fat-specific protein FSP27 homolog
SpeciesHuman
Gene ID63924
UniprotQ96AQ7,
Species.1Mouse
Gene ID.1
Uniprot.1P56198
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus . Endoplasmic reticulum. Lipid droplet. Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites.
Tissue ExpressionExpressed mainly in adipose tissue, small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver.
Signaling_pathway
Research Areas
FunctionFunction:Isoforms 1 and 2 induce apoptosis.,similarity:Contains 1 CIDE-N domain.,subcellular location:Cytoplasmic in a punctate manner.,tissue specificity:Expressed mainly in small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver.,
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