SKU: WP11675 Categories: ,

CLIP3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11675-100
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Product details

Background:

This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010],

Specifications

Size50μL/100μL
TargetCLIP3
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)60kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CLIP3. AA range:361-410
SpecificityCLIP3 Polyclonal Antibody detects endogenous levels of CLIP3 protein.
Gene NameCLIP3
Protein NameCAP-Gly domain-containing linker protein 3
Other NameCLIP3; / CLIPR59; / CAP-Gly domain-containing linker protein 3; / Cytoplasmic linker protein 170-related 59 kDa protein; / CLIP-170-related 59 kDa protein; / CLIPR-59
SpeciesHuman
Gene ID25999
UniprotQ96DZ5,
Species.1Mouse
Gene ID.176686
Uniprot.1B9EHT4
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Lipid-anchor . Cytoplasm . Golgi apparatus, Golgi stack . Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.
Tissue ExpressionBrain,Skin,Uterus,
Signaling_pathway
Research Areas
FunctionDomain:Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD).,Function:Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics.,miscellaneous:The N-terminal half is dispensable for proper Golgi targeting, whereas the GoLD region is required.,similarity:Contains 2 CAP-Gly domains.,similarity:Contains 3 ANK repeats.,subcellular location:Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.,subunit:Homodimer.,
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