SKU: WP11698 Categories: ,

CNK2 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11698-100
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Product details

Background:

This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009],

Specifications

Size50μL/100μL
TargetCNK2
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)117kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CNKR2. AA range:641-690
SpecificityCNK2 Polyclonal Antibody detects endogenous levels of CNK2 protein.
Gene NameCNKSR2
Protein NameConnector enhancer of kinase suppressor of ras 2
Other NameCNKSR2; / CNK2; / KIAA0902; / KSR2; / Connector enhancer of kinase suppressor of ras 2; / Connector enhancer of KSR 2; / CNK homolog protein 2; / CNK2
SpeciesHuman
Gene ID22866
UniprotQ8WXI2,
Species.1Mouse
Gene ID.1245684
Uniprot.1Q80YA9,
Species.2Rat
Gene ID.259322
Uniprot.2Q9Z1T4
Cellular LocalizationCytoplasm. Membrane; Peripheral membrane protein.
Tissue ExpressionBrain,Fetal brain,
Signaling_pathway
Research Areas
FunctionFunction:May function as an adapter protein or regulator of Ras signaling pathways.,PTM:Phosphorylated on tyrosine.,similarity:Belongs to the CNKSR family.,similarity:Contains 1 CRIC domain.,similarity:Contains 1 DUF1170 domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,subunit:Interacts with RAF1, RAB2L and RAL GTPase proteins.,
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