Name: COX-2 [ABT-COX2] mouse mAb
SKU: WM1663
Price: 268 USD
Availability: InStock

Product details

Background:
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009],

Specifications

Size	50μL/100μL
Target	COX2
Reactivity	Human
Applications	IHC, ELISA
MW(Calculated)	69kD
MW(Observed)	70kD
Host Species	Mouse
Isotype	IgG2b,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-400; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMM-COX2
Immunogen	Synthesized peptide derived from human COX-2 (cyclooxygenase-2) AA range: 500-604
Specificity	The antibody can specifically recognize human COX-2 protein.
Gene Name	PTGS2 COX2
Protein Name	Prostaglandin G/H synthase 2 (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)
Other Name
Species	Human
Gene ID	5743
Uniprot	P35354
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasmic
Tissue Expression	Endothelial cell,Epidermal keratinocytes in primary culture,Lung,Pe
Signaling_pathway	Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Human Diseases >> Cancer: specific types >> Small cell lung cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> VEGF signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway
Research Areas	>>Arachidonic acid metabolism; / >>Metabolic pathways; / >>NF-kappa B signaling pathway; / >>VEGF signaling pathway; / >>C-type lectin receptor signaling pathway; / >>IL-17 signaling pathway; / >>TNF signaling pathway; / >>Retrograde endocannabinoid signaling; / >>Serotonergic synapse; / >>Ovarian steroidogenesis; / >>Oxytocin signaling pathway; / >>Regulation of lipolysis in adipocytes; / >>Alzheimer disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Leishmaniasis; / >>Human cytomegalovirus infection; / >>Human papillomavirus infection; / >>Kaposi sarcoma-associated herpesvirus infection; / >>Pathways in cancer; / >>Chemical carcinogenesis - DNA adducts; / >>MicroRNAs in cancer; / >>Small cell lung cancer
Function	Catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,Disease:Likely to play a role in inflammatory diseases such as rheumatoid arthritis.,Function:May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.,induction:By cytokines and mitogens.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,