Cripto Monoclonal Antibody
Ucallm_WM0123-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
Specifications
| Size | 50μL/100μL |
| Target | Cripto |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 21kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 17F2 |
| Immunogen | Purified recombinant fragment of human Cripto expressed in E. Coli. |
| Specificity | Cripto Monoclonal Antibody detects endogenous levels of Cripto protein. |
| Gene Name | TDGF1 |
| Protein Name | Teratocarcinoma-derived growth factor 1 |
| Other Name | TDGF1; / CRIPTO; / Teratocarcinoma-derived growth factor 1; / Cripto-1 growth factor; / CRGF; / Epidermal growth factor-like cripto protein CR1 |
| Species | Human |
| Gene ID | 6997 |
| Uniprot | P13385, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P51865 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor . Secreted . Released from the cell membrane by GPI cleavage. . |
| Tissue Expression | Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.,similarity:Contains 1 EGF-like domain.,tissue specificity:Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts., |
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