SKU: WP11804 Categories: ,

CROT Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11804-100
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Product details

Background:

This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4, 8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009],

Specifications

Size50μL/100μL
TargetCROT
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF, ELISA
MW(Calculated)
MW(Observed)72kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from CROT . at AA range: 190-270
SpecificityCROT Polyclonal Antibody detects endogenous levels of CROT protein.
Gene NameCROT
Protein NamePeroxisomal carnitine O-octanoyltransferase
Other NameCROT; / COT; / Peroxisomal carnitine O-octanoyltransferase; / COT
SpeciesHuman
Gene ID54677
UniprotQ9UKG9,
Species.1Mouse
Gene ID.174114
Uniprot.1Q9DC50,
Species.2Rat
Gene ID.283842
Uniprot.2P11466
Cellular LocalizationPeroxisome .
Tissue ExpressionBrain,Skin,
Signaling_pathwayCellular Processes >> Transport and catabolism >> Peroxisome
Research Areas>>Peroxisome
FunctionCatalytic activity:Octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine.,Function:Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.,pathway:Lipid metabolism; fatty acid beta-oxidation.,similarity:Belongs to the carnitine/choline acetyltransferase family.,subunit:Monomer.,
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